Open Clinical Trials

Breast

  • An Open-Label, Multicenter, Randomized, Phase 2 Study Evaluating the Efficacy and Safety of Ramucirumab Drug Product (IMC-1121B) in Combination with Eribulin Versus Eribulin Monotherapy in Unresectable, Locally-Recurrent or Metastatic Breast Cancer Patients Previously Treated with Anthracycline and Taxane Therapy
    Available at: Metropolitan,  Northeast,  Stone Oak, 
  • A Phase II, Multicenter, Single-Arm, Feasibility Study of Eribulin in Combination with Capecitabine for Adjuvant Treatment in Estrogen Receptor-Postive Early Stage Breast Cancer
    Available at: Kerrville,  Metropolitan,  Northeast,  Stone Oak, 
  • A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation and Radiation Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy
    Available at: Kerrville,  Northeast,  Stone Oak, 
  • A Randomized, Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, or II Breast Cancer
    Available at: Northeast, 
  • A Randomized, Phase II Study of AFP464 +/- Faslodex in ER-positive Breast Cancer Patients Who Have Progressed on Aromatase Inhibitor Therapy
    Available at: Medical Center,  New Braunfels, 
  • A Phase 2, Multicenter, Single-Arm Study of Eribulin Mesylate with Trastuzumab as First-Line Therapy for Locally Recurrent or Metastatic Human Epidermal Growth Factor Receptor Two (HER2) Positive Breast Cancer
    Available at: Kerrville,  Northeast,  Stone Oak, 
  • Randomized, Double-Blind, Placebo Controlled, Multi-Center Phase 3 Study of Denosumab as Adjuvant Treatment for Women with Early Stage Breast Cancer at HIgh Risk of Recurrence
    Available at: Kerrville,  Metropolitan,  Northeast,  Stone Oak, 
  • A Randomized, Phase III, Double-Blind, Placebo-Controlled Multicenter Trial of Daily Everolimus in Combination with Trastuzumab and Vinorelbine, in Pretreated Women with HER2/neu Over-Expressing Locally Advanced or Metastatic Breast Cancer
    Available at: Kerrville,  Metropolitan,  Northeast,  Stone Oak, 
  • A Phase III Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women with Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer
    Available at: Kerrville,  Medical Center,  New Braunfels,  Northeast,  Stone Oak, 

Breast Cancer and Bone Metastases

  • A Prospective, Randomized Double-Blind, Stratified, Placebo-Controlled, Multi-Center, Three-Arm Trial of the Continued Efficacy and Safety of Zometa (every 4 weeks vs. every 12 weeks vs. placebo) in Patients with Documented Bone Metastases from Breast Cancer
    Available at: Medical Center,  New Braunfels, 

Colorectal

  • A Randomized, Double Blind, Multicenter Phase 3 Study of Irinotecan, Folinic Acid, and 5-Fluorouracil Plus Ramucirumab or Placebo in Patients with Metastatic Colorectal Carcinoma Progressive During or Following First-Line Combination Therapy with Bevacizumab, Oxaliplatin, and a Fluoropyrimidine
    Available at: Kerrville,  Medical Center,  Metropolitan,  New Braunfels,  Northeast,  Stone Oak, 

DVT

  • A Phase 3, Randomized, Double-Blind, Double-Dummy, Parallel-Group, Multicenter Study for the Evaluation of Efficacy and Safey of (LMW) Heparin/Edoxaban Versus (LMW) Heparin/Warfarin in Subjects with Symptomatic Deep-Vein Thrombosis and/or Pulmonary Embolism
    Available at: Medical Center,  New Braunfels, 
  • A Safety and Efficacy Trial Evaluating the Use of Apixaban in the Treatment of Symptomatic Deep Vein Thrombosis and Pulmonary Embolism
    Available at: Medical Center,  New Braunfels, 

Genitourinary

  • Radiation Therapy Clinical Trial: A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy in Prostate Cancer Patients With a Rising PSA AFter Radical Prostatectomy
    Available at: Northeast, 

Head and Neck

  • A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients with Esophageal Cancer Who are Treated Without Surgery
    Available at: Northeast, 
  • Radiation Therapy Clinical Trial: A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer
    Available at: Northeast, 

ITP (Idiopathic Thrombocytopenic Purpura)

  • Phase I/II Study of Immunotherapy with Humanized Anti-CD20 Antibody, IMMU-106 (hA20) in Adults with Chronic ITP
    Available at: Medical Center,  New Braunfels, 

Leukemia (CLL, CML)

  • Studying Interventions for Managing Patients with Chronic Myeloid Leukemia in Chronic Phase: The 5-Year Prospective Cohort Study
    Available at: Kerrville,  Northeast,  Stone Oak, 
  • A Phase III, Randomized, Controlled, Double-Blind, Multinational Clinical Study of the Efficacy and Safety of Vosaroxin and Cytarabine Versus Placebo and Cytarabine in Patients with First Relapsed or Refractory Acute Myeloid Leukemia
    Available at: Medical Center, 
  • An Exploratory Trial to Assess the Improvement of Chronic Low-Grade Non-Hematologic Adverse Events Experienced by Patient with Phiadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase Treated with Imatinib When Switched to Nilotinib Treatment
    Available at: Kerrville,  Medical Center,  New Braunfels,  Northeast,  Stone Oak, 

Lung

  • A Randomized, Double-Blind, Phase 3 Study of Docetaxel and Ramucirumab versus Docetaxel and Placebo in the Treatment of Stage IV Non-Small Cell Lung Cancer Following Disease Progression after One Prior Platinum-Based Therapy
    Available at: Metropolitan,  Northeast,  Stone Oak, 
  • A Randomized, Double-Blind, Phase 3 Study of Docetaxel and Ramucirumab versus Docetaxel and Placebo in the Treatment of Stage IV Non-Small Cell Lung Cancer Following Disease Progression after One Prior Platinum-Based Therapy
    Available at: Kerrville,  Medical Center,  New Braunfels,  Southeast,  Stone Oak, 
  • Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Long-Term Safety and Efficacy of Darbepoetin Alfa Administered at 500 ig Once-Every-3-Weeks to a Hemoglobiin Ceiling of 12.0 g/dl in Anemic Subjects with Advanced Stage Non-Small Cell Lung Cancer Receiving Multi-Cycle Chemotherapy
    Available at: Kerrville,  Medical Center,  New Braunfels,  Northeast,  Stone Oak, 

Lymphoma

  • Phase II Open-Label Study of Ofatumumab and Bendamustine Followed by Maintenance Ofatumumab for Indolent B-cell Non-Hodgkin's Lymphoma (B-NHL) Which Has Relapsed After Rituximab Therapy
    Available at: Medical Center,  New Braunfels, 
  • A Open-Label, Randomized, Phase 2 Study to Assess the Effectiveness of RCHOP With or Without VELCADE in Previously Untreated Patients with Non-Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma
    Available at: Kerrville,  Metropolitan,  Northeast,  Stone Oak, 
  • A Randomized, Multicenter Study Comparing Pixantrone + Rituximab with Gemcitabine + Rituximab in Patients With Agressive B-Cell Non-Hodgkins Lymphoma Who Have Relapsed After Therapy with CHOP-R or an Equivalent Regimen and are Ineligible for Stem Cell Transplant
    Available at: Medical Center,  New Braunfels, 

Multiple Myeloma

  • A Phase III, Randomized Study to Assess the Efficacy and Safety of Perifosine Added to the Combination of Bortezomib and Dexamethasone in Multiple Myeloma Patients Previously Treated with Bortezomib
    Available at: Medical Center,  New Braunfels, 

Myelodysplasia

  • A Phase I, Open Label, Dose Escalation Study to Evaluate the Safety, PK, and PD of oral Azacitidine in Subjects with MDS, CMML, or AML (Currently enrolling only for MDS)
    Available at: Medical Center, 
  • A Phase III Multicenter Randomized, Controlled Study to Assess the Efficacy and Safety of ONO1919/Na Administered as a 72 Hr. Continuous Intravenous Infusion Every Other Week in MDS patients with Excess Blasts Relapsing After, or Refractory to , or Intolerant to Azacitidine or Decitabine
    Available at: Medical Center,  New Braunfels, 
  • A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Deferasirox in Patients with Myelodysplastic Syyndromes (low/int-1 Risk) and Transfusional Iron Overload
    Available at: Kerrville,  Medical Center,  New Braunfels,  Northeast,  Stone Oak, 
  • A Phase I/II Study of Eltrombopag in Thrombocytopenic Subjects with Advanced MDS or Secondary AML after MDS
    Available at: Medical Center,  New Braunfels, 

Pancreatic

  • A Phase I/Randomized Phase 2 Study to Evaluate LY2603618 in Combination with Gemcitabine in Patients with Pancreatic Cancer
    Available at: Metropolitan,  Northeast,  Stone Oak, 

Primary Myelofibrosis/Post-Essential Myelofibrosis/Post-Polycythemia Vera Myelofibrosis

  • An Open Label Assessment of Alternative Dosing Strategies of Ruxolitinib in Patients with Primary Myelofibrosis, Post-Polycythemia Vera-Myelofibrosis and Post-Essential Thrombocythemia-Myelofibrosis
    Available at: Medical Center,  New Braunfels, 
  • Randomized, Open-Label, Multicenter, Phase III Study of Efficacy and Safety in Polycythemia Vera Subjects Who are Resistant To or Intolerant Of Hydroxyurea: JAK INC424 Tablets Versus Best Available Care
    Available at: Medical Center,  New Braunfels, 
  • Open Label Assessment of Safety and Efficacy of Ruxolitinib in Patients with Primary Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis and Post-Polycythemia Vera-Myelofibrosis Who Have Platelet Counts of 50 to 100
    Available at: Medical Center,  New Braunfels, 

Renal Cell

  • An Open-Label, Randomized, Multi-Center Phase III Study to Compare the Safety and Efficacy of TK1258 Versus Sorafenib in Patients with Metastastic Renal Cell Carcinoma After Failure of Anti-Angiogenic (VEGF-targeted and mTOR inhibitor therapies)
    Available at: Kerrville,  Northeast,  Stone Oak, 

Sarcoma

  • A Phase III Multicenter, International, Randomized, Double-Blind, Placebo-Controlled Study of Doxorubicin plus Palifosfamide-tris vs. Doxorubicin Plus Placebo in Patients with Front-Line Metastatic Soft Tissue Sarcoma
    Available at: Kerrville,  Northeast,  Stone Oak, 

Severe Chronic Neutropenia

  • Phase 2, Randomized Study of Ezatiostat Hydrochloride (Telindra, TLK199 Tablets) for Treatment of SCN
    Available at: Medical Center,  New Braunfels, 

Supportive Care

  • A Phase III, Randomized, Placebo-Controlled, Clinical Trial to Study the Safety and Efficacy of V212 in Adult Patients with Solid Tumor or Hematologic Malignancy
    Available at: Medical Center, 
  • Precision Therapeutics Registry Multicenter, Post Market Follow Up Study of ChemoFx Chemo Response Assay in Solid Tumors-ChemoFx Registry Study
    Available at: Medical Center,  New Braunfels, 
  • Registry of Caris Target Now Test Results (Biomarker Expression Patterns) and Hematopoietic Diagnostics for Evaluation of Correlation with Clinical Outcomes for Cancer and Other Patients
    Available at: Medical Center,  New Braunfels, 
  • An Assessment of Chemotherapy-Induced Nausea and Vomiting from a Patient-Centered Outcomes Research Perspective
    Available at: Kerrville,  Medical Center,  Metropolitan,  New Braunfels,  Northeast,  Stone Oak, 

Tissue Sample Collection

  • Collection of Patients' Tumor Tissue for Analysis of Molecular Markers that Predict for Benefit from Cancer Therapies (Open only to AFP464+/- Faslodex breast clinical trial)
    Available at: Medical Center,  New Braunfels,